Hemolytic Activity and Cytotoxicity of Synthetic Nanoclays with Montmorillonite Structure for Medical Applications.

ABSTRACT: The factors influencing the appearance of toxicity in samples of synthetic montmorillonite with a systematically changing chemical composition Na_x(Al, Mg)_2-3Si₄O₁₀(OH)₂ nH₂O, which are potentially important for their use in medicine as drug carriers, targeted drug delivery systems, entero- and hemosorbents have been studied. Samples synthesized under hydrothermal conditions had the morphology of nanolayers self-organized into the nanosponge structures. The effect of the aluminum content, particle sizes, porosity, and ζ-potential of the samples on their toxicity was studied. The cytotoxic effect of the samples on eukaryotic cells Ea. hy 926 was determined using the MTT assay. The hemolytic activity of the samples in th

SUBMITTER: Golubeva OY 

PROVIDER: S-EPMC10180290 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature