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Synthesis, Quality Control and Preliminary Activity Evaluation of a New Compound HM475.

ABSTRACT: Based on the principle of molecular splicing and theory of traditional Chinese medicine pairs, a new multi-active compound (HM475) was synthesized by connecting metformin with honokiol, and its structure was characterized, which not only reduced the toxicity of raw materials, but also maintained the original activity, and had a certain significance in research and innovation. At the same time, quality control and preliminary activity evaluation were carried out, and the effect of HM475 on neuroinflammation was further explored, which provided a new idea for drug development of neurodegenerative diseases.

SUBMITTER: Guo J

PROVIDER: S-EPMC10180444 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Synthesis, Quality Control and Preliminary Activity Evaluation of a New Compound HM475.

Guo Jieqing J Xie Luming L Zhang Jing J Cao Han H Wang Juanxia J Wu Xia X Feng Yifan Y

Molecules (Basel, Switzerland) 20230427 9

Based on the principle of molecular splicing and theory of traditional Chinese medicine pairs, a new multi-active compound (HM475) was synthesized by connecting metformin with honokiol, and its structure was characterized, which not only reduced the toxicity of raw materials, but also maintained the original activity, and had a certain significance in research and innovation. At the same time, quality control and preliminary activity evaluation were carried out, and the effect of HM475 on neuroi ...[more]

PMID: 37175163

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