Biological Evaluation of Triorganotin Derivatives as Potential Anticancer Agents.

ABSTRACT: Metal-derived platinum complexes are widely used to treat solid tumors. However, systemic toxicity and tumor resistance to these drugs encourage further research into similarly effective compounds. Among others, organotin compounds have been shown to inhibit cell growth and induce cell death and autophagy. Nevertheless, the impact of the ligand structure and mechanisms involved in the toxicity of organotin compounds have not been clarified. In the present study, the biological activities of commercially available bis(tributyltin) oxide and tributyltin chloride, in comparison to those of specially synthesized tributyltin trifluoroacetate (TBT-OCOCF₃) and of cisplatin, were assessed using cells with different levels of tumorigenicity. The results show that tributyltins were more c

SUBMITTER: Stefanizzi V 

PROVIDER: S-EPMC10180515 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature