Branched-Chain Amino Acids Metabolism and Their Roles in Retinopathy: From Relevance to Mechanism.

ABSTRACT: Retinopathy is one of the leading causes of irreversible blindness and vision loss worldwide. Imbalanced nutrients play important roles in the pathogenesis and pathophysiology of retinal diseases. Branched-Chain Amino Acids (BCAAs), as essential amino acids, perform a variety of biological functions, including protein synthesis, glucose metabolism, lipid metabolism, inflammation, and oxidative stress in metabolic tissues of diabetes and aging-related diseases. Recently, it has been shown that BCAAs are highly related to neuroprotection, oxidative stress, inflammatory and glutamate toxicity in the retina of retinopathy. Therefore, this review summarizes the alterations of BCAA levels in retinopathy, especially diabetic retinopathy and aging-related macular disease, and the genetics, functio

SUBMITTER: Zhang X 

PROVIDER: S-EPMC10180926 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature