Development of Hybrid DSPC:DOPC:P(OEGMA₉₅₀-DIPAEMA) Nanostructures: The Random Architecture of Polymeric Guest as a Key Design Parameter.

ABSTRACT: Hybrid nanoparticles have gained a lot of attention due to their advantageous properties and versatility in pharmaceutical applications. In this perspective, the formation of novel systems and the exploration of their characteristics not only from a physicochemical but also from a biophysical perspective could promote the development of new nanoplatforms with well-defined features. In the current work, lipid/copolymer bilayers were formed in different lipid to copolymer ratios and examined via differential scanning calorimetry as a preformulation study to decipher the interactions between the biomaterials, followed by nanostructure preparation by the thin-film hydration method. Physicochemical and toxicological evaluations were conducted utilizing light scattering techniques, fluorescence

SUBMITTER: Triantafyllopoulou E 

PROVIDER: S-EPMC10181429 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature