Development of a shortwave infrared sinuscope for the detection of cerebrospinal fluid leaks.

ABSTRACT:

Significance

Cerebrospinal fluid (CSF) rhinorrhea (leakage of brain fluid from the nose) can be difficult to identify and currently requires invasive procedures, such as intrathecal fluorescein, which requires a lumbar drain placement. Fluorescein is also known to have rare but significant side effects including seizures and death. As the number of endonasal skull base cases increases, the number of CSF leaks has also increased for which an alternative diagnostic method would be highly advantageous to patients.

Aim

We aim to develop an instrument to identify CSF leaks based on water absorption in the shortwave infrared (SWIR) without the need of intrathecal contrast agents. This device needed to be adapted to the anatomy of the human nasal cavity while maintaining low weight

SUBMITTER: Klein TW 

PROVIDER: S-EPMC10181794 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature