Viral dynamics of SARS-CoV-2 in immunocompromised patients.

ABSTRACT:

Objectives

Immunocompromised patients infected with SARS-CoV-2 have been shown to shed replicable virus for a prolonged period of time, and the duration of isolation can therefore be difficult to estimate. The objective of this study was to evaluate the viral load dynamic in non-hospitalized immunocompromised patients infected with SARS-CoV-2 and treated with monoclonal antibodies or antivirals.

Methods

Oropharyngeal swabs for real time polymerase chain reaction (RT-PCR) and viral culture were collected from 29 immunocompromised patients before treatment with monoclonal antibodies or antivirals and at day 5 and 15 after treatment. Overall, 12 patients were infected with the subvariant Omicron BA.1, 12 with Omicron BA.2, two with the Delta-variant and for three patients deter

SUBMITTER: Utzon AN 

PROVIDER: S-EPMC10181867 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature