Aqueous cannabidiol β-cyclodextrin complexed polymeric micelle nasal spray to attenuate in vitro and ex vivo SARS-CoV-2-induced cytokine storms.

ABSTRACT: Cannabidiol (CBD) has a number of biological effects by acting on the cannabinoid receptors CB₁ and CB₂. CBD may be involved in anti-inflammatory processes via CB₁ and CB₂ receptors, resulting in a decrease of pro-inflammatory cytokines. However, CBD's poor aqueous solubility is a major issue in pharmaceutical applications. The aim of the present study was to develop and evaluate a CBD nasal spray solution. A water-soluble CBD was prepared by complexation with β-cyclodextrin (β-CD) at a stoichiometric ratio of 1:1 and forming polymeric micelles using poloxamer 407. The mixture was then lyophilized and characterized using FT-IR, DSC, and TGA. CBD-β-CD complex-polymeric micelles were formulated for nasal spray drug delivery. The physicochemical pro

SUBMITTER: Changsan N 

PROVIDER: S-EPMC10181874 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature