Taurine Promotes Differentiation and Maturation of Neural Stem/Progenitor Cells from the Subventricular Zone via Activation of GABA_A Receptors.

ABSTRACT: Neurogenesis, the formation of new neurons in the brain, occurs throughout the lifespan in the subgranular zone of the dentate gyrus and subventricular zone (SVZ) lining the lateral ventricles of the mammal brain. In this process, gamma-aminobutyric acid (GABA) and its ionotropic receptor, the GABA_A receptor (GABA_AR), play a critical role in the proliferation, differentiation, and migration process of neural stem/progenitor cells (NPC). Taurine, a non-essential amino acid widely distributed throughout the central nervous system, increases the proliferation of SVZ progenitor cells by a mechanism that may involve GABA_AR activation. Therefore, we characterized the effects of taurine on the differentiation process of NPC expressing GABA_AR. Preincubat

SUBMITTER: Gutierrez-Castaneda NE 

PROVIDER: S-EPMC10181976 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature