Modular architecture and resilience of structural covariance networks in first-episode antipsychotic-naive psychoses.

ABSTRACT: Structural covariance network (SCN) studies on first-episode antipsychotic-naïve psychosis (FEAP) have examined less granular parcellations on one morphometric feature reporting lower network resilience among other findings. We examined SCNs of volume, cortical thickness, and surface area using the Human Connectome Project atlas-based parcellation (n = 358 regions) from 79 FEAP and 68 controls to comprehensively characterize the networks using a descriptive and perturbational network neuroscience approach. Using graph theoretical methods, we examined network integration, segregation, centrality, community structure, and hub distribution across the small-worldness threshold range and correlated them with psychopathology severity. We used simulated nodal "attacks" (removal of nodes and all t

SUBMITTER: Lewis M 

PROVIDER: S-EPMC10181992 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature