Effect of basal metabolic rate on lifespan: a sex-specific Mendelian randomization study.

ABSTRACT: Observationally, the association of basal metabolic rate (BMR) with mortality is mixed, although some ageing theories suggest that higher BMR should reduce lifespan. It remains unclear whether a causal association exists. In this one-sample Mendelian randomization study, we aimed to estimate the casual effect of BMR on parental attained age, a proxy for lifespan, using two-sample Mendelian randomization methods. We obtained genetic variants strongly (p-value < 5 × 10^-8) and independently (r² < 0.001) predicting BMR from the UK Biobank and applied them to a genome-wide association study of parental attained age based on the UK Biobank. We meta-analyzed genetic variant-specific Wald ratios using inverse-variance weighting with multiplicative random effects by sex, suppl

SUBMITTER: Ng JCM 

PROVIDER: S-EPMC10182013 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature