Utility of [⁶⁸Ga]FAPI-04 and [¹⁸F]FDG dual-tracer PET/CT in the initial evaluation of gastric cancer.

ABSTRACT:

Objectives

We aimed to investigate the role of [⁶⁸Ga]FAPI-04 and [¹⁸F]FDG dual-tracer PET/CT for the initial assessment of gastric cancer and to explore the factors associated with their uptake.

Methods

This study enrolled 62 patients with histopathologically confirmed gastric cancer. We compared the diagnostic performance of [⁶⁸Ga]FAPI-04, [¹⁸F]FDG, and combined dual-tracer PET/CT. The standardized uptake value (SUV) and tumor-to-background ratio (TBR) were also measured, and the factors that influence tracer uptake were analyzed.

Results

[⁶⁸Ga]FAPI-04 PET/CT detected more primary lesions (90.3% vs 77.4%, p = 0.008) and peritoneal metastases (91.7% vs 41.7%, p = 0.031) and demonstrated higher SUV_max an

SUBMITTER: Miao Y 

PROVIDER: S-EPMC10182135 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature