Predicting pathological complete response of neoadjuvant radiotherapy and targeted therapy for soft tissue sarcoma by whole-tumor texture analysis of multisequence MRI imaging.

ABSTRACT:

Objectives

To construct effective prediction models for neoadjuvant radiotherapy (RT) and targeted therapy based on whole-tumor texture analysis of multisequence MRI for soft tissue sarcoma (STS) patients.

Methods

Thirty patients with STS of the extremities or trunk from a prospective phase II trial were enrolled for this analysis. All patients underwent pre- and post-neoadjuvant RT MRI examinations from which whole-tumor texture features were extracted, including T₁-weighted with fat saturation and contrast enhancement (T₁FSGd), T₂-weighted with fat saturation (T₂FS), and diffusion-weighted imaging (DWI) sequences and their corresponding apparent diffusion coefficient (ADC) maps. According to the postoperative pathological results

SUBMITTER: Miao L 

PROVIDER: S-EPMC10182155 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature