Vancomycin Clearance in Obese Adults is not Predictive of Clearance in Obese Adolescents.

ABSTRACT:

Background and objective

Contradictory pharmacokinetic (PK) results have been observed between obese adults and obese adolescents, with absolute clearance (CL) reported to be either unaltered, lower, or higher in obese adolescents compared to obese adults. This study investigates the PK of vancomycin in adolescents and adults who are overweight or obese.

Methods

Data from 125 overweight and obese adolescents (aged 10-18 years, weight 28.3-188 kg) and 81 overweight and obese adults (aged 29-88 years, weight 66.7-143 kg) were analysed using population PK modelling. In addition to age, sex, renal function estimates, and regular weight descriptors, we evaluated standard weight (WT_standard, defined as weight for length, age, and sex in adolescents and weight for length

SUBMITTER: Zhang T 

PROVIDER: S-EPMC10182161 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature