Dysregulated brain regulatory T cells fail to control reactive gliosis following repeated antigen stimulation.

ABSTRACT: This study was undertaken to investigate the role of CD4+FoxP3+ regulatory T cells (Tregs) in regulating neuroinflammation during viral Ag-challenge and re-challenge. CD8⁺ lymphocytes persisting within tissues are designated tissue-resident memory T cells (T_RM), within brain: bT_RM. Reactivation of bT_RM with T cell epitope peptides generates rapid antiviral recall, but repeated stimulation leads to cumulative dysregulation of microglial activation, proliferation, and prolonged neurotoxic mediator production. Here, we show Tregs were recruited into murine brains following prime-CNS boost, but displayed altered phenotypes following repeated Ag-challenge. In response to repeated Ag, brain Tregs (bTregs) displayed inefficient immunosuppressive capacit

SUBMITTER: Prasad S 

PROVIDER: S-EPMC10182273 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature