Increased Histological Tumor Pigmentation in Uveal Melanoma Is Related to Eye Color and Loss of Chromosome 3/BAP1.

ABSTRACT:

Purpose

Heavy pigmentation is known to be a prognostic risk factor in uveal melanoma (UM). We analyzed whether genetic tumor parameters were associated with tumor pigmentation and whether pigmentation should be included in prognostic tests.

Design

Retrospective comparison of clinical, histopathological, and genetic features and survival in UM with different pigmentation.

Participants

A total of 1058 patients with UM from a White European population with diverse eye colors enucleated between 1972 and 2021.

Methods

Cox regression and log-rank tests were used for survival analysis; the chi-square test and Mann-Whitney U test were used for correlation analysis.

Main outcome measures

Uveal melanoma-related survival based on tumor pigmentation and chrom

SUBMITTER: Gelmi MC 

PROVIDER: S-EPMC10182323 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature