Association of Hospital Adoption of Probiotics With Outcomes Among Neonates With Very Low Birth Weight.

ABSTRACT:

Importance

For neonates with very low birth weight (VLBW), randomized clinical trials (RCTs) indicate that probiotic treatment decreases the risk of necrotizing enterocolitis (NEC), with smaller decreases in the risk of sepsis and death. There is little evidence on the rate of probiotic adoption in US neonatal intensive care units (NICUs) and whether the benefits seen in trials have materialized in practice.

Objective

To estimate changes in probiotic use among neonates with VLBW and to test whether neonates with VLBW treated at NICUs adopting routine probiotic use experience better outcomes compared with neonates treated at nonadopting NICUs.

Design, setting, and participants

This cohort study used Vermont Oxford Network data on neonates with VLBW in US NICUs from Jan

SUBMITTER: Agha L 

PROVIDER: S-EPMC10182437 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature