Effect of dexmedetomidine on postoperative cognitive dysfunction and the T helper 17/regulatory T cell balance in geriatric patients undergoing orthopedic surgery: a randomized controlled study.

ABSTRACT:

Objectives

To investigate the effect of dexmedetomidine (DEX) on alleviating postoperative cognitive dysfunction (POCD) and T helper 17 (Th17)/regulatory T cell (Treg) imbalance in geriatric patients undergoing orthopedic surgery.

Methods

A total of 82 geriatric patients undergoing lower extremity joint replacement surgery were enrolled and randomized into two groups. Patients in the experimental group received a loading dose of 0.5 µg/kg DEX for 10 min and then a maintenance dose of 0.5 µg/kg/h DEX until 30 min before the end of the surgery, while patients in the control group were administered with an equal volume of saline. The mini-mental state examination (MMSE) was used to evaluate the patients' cognitive function levels. The enzyme-linked immunosorbent assay (ELISA) w

SUBMITTER: Zhao W 

PROVIDER: S-EPMC10182492 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature