An immunogenic cell death-related classification predicts response to immunotherapy and prognosis in triple-negative breast cancer.

ABSTRACT:

Objective

Immunogenic cell death (ICD) of tumor cells is characterized by the induction of adaptive and innate immune responses, which in turn activates the immune surveillance and improves the efficacy of immunotherapy. In this study, we aimed to investigate the effect of ICD on the prognosis and the efficacy of immunotherapy in patients with triple-negative breast cancer (TNBC).

Methods

TNBC samples from The Cancer Genome Atlas-Breast Cancer (TCGA-BRCA) dataset were divided into two subtypes (ICD-high and ICD-low) based on the ICD status by using the consensus clustering method, and their genomic landscape and immune landscape were delineated. Furthermore, we established an ICD-related prognostic model to predict the efficacy of immunotherapy and the survival of TNBC.

R

SUBMITTER: Cheng XY 

PROVIDER: S-EPMC10182501 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature