Membrane tension-mediated stiff and soft tumor subtypes closely associated with prognosis for prostate cancer patients.

ABSTRACT:

Background

Prostate cancer (PCa) is usually considered as cold tumor. Malignancy is associated with cell mechanic changes that contribute to extensive cell deformation required for metastatic dissemination. Thus, we established stiff and soft tumor subtypes for PCa patients from perspective of membrane tension.

Methods

Nonnegative matrix factorization algorithm was used to identify molecular subtypes. We completed analyses using software R 3.6.3 and its suitable packages.

Results

We constructed stiff and soft tumor subtypes using eight membrane tension-related genes through lasso regression and nonnegative matrix factorization analyses. We found that patients in stiff subtype were more prone to biochemical recurrence than those in soft subtype (HR 16.18; p < 0.001), w

SUBMITTER: Feng D 

PROVIDER: S-EPMC10182623 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature