Assessing the relationship between gut microbiota and irritable bowel syndrome: a two-sample Mendelian randomization analysis.

ABSTRACT:

Background

Growing evidence has suggested that gut microbiota is closely related to the risk of irritable bowel syndrome (IBS), but whether there is a causal effect remains unknown. We adopted a Mendelian randomization (MR) approach to evaluate the potential causal relationships between gut microbiota and the risk of IBS.

Methods

Genetic instrumental variables for gut microbiota were identified from a genome-wide association study (GWAS) of 18,340 participants. Summary statistics of IBS were drawn from a GWAS including 53,400 cases and 433,201 controls. We used the inverse-variance weighted (IVW) method as the primary analysis. To test the robustness of our results, we further performed the weighted-median method, MR-Egger regression, and MR pleiotropy residual sum and outli

SUBMITTER: Liu B 

PROVIDER: S-EPMC10182631 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature