Dual trajectories of antiretroviral therapy adherence and polypharmacy in women with HIV in the United States.

ABSTRACT:

Background

Polypharmacy, using five or more medications, may increase the risk of nonadherence to prescribed treatment. We aimed to identify the interrelationship between trajectories of adherence to antiretroviral therapy (ART) and polypharmacy.

Methods

We included women with HIV (aged ≥ 18) enrolled in the Women's Interagency HIV Study in the United States from 2014 to 2019. We used group-based trajectory modeling (GBTM) to identify trajectories of adherence to ART and polypharmacy and the dual GBTM to identify the interrelationship between adherence and polypharmacy.

Results

Overall, 1,538 were eligible (median age of 49 years). GBTM analysis revealed five latent trajectories of adherence with 42% of women grouped in the consistently moderate trajectory. GBTM ident

SUBMITTER: Elbur AI 

PROVIDER: S-EPMC10182649 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature