CEP55: an immune-related predictive and prognostic molecular biomarker for multiple cancers.

ABSTRACT:

Background

Centrosomal protein 55 (CEP55) plays a significant role in specific cancers. However, comprehensive research on CEP55 is lacking in pan-cancer.

Methods

In-house and multi-center samples (n = 15,823) were used to analyze CEP55 in 33 cancers. The variance of CEP55 expression levels among tumor and control groups was evaluated by the Wilcoxon rank-sum test and standardized mean difference (SMD). The clinical value of CEP55 in cancers was assessed using receiver operating characteristic (ROC) curves, Cox regression analysis, and Kaplan-Meier curves. The correlations between CEP55 expression and the immune microenvironment were explored using Spearman's correlation coefficient.

Results

The data of clustered regularly interspaced short palindromic repeats confirm

SUBMITTER: Li GS 

PROVIDER: S-EPMC10182662 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature