Pre-eclampsia during pregnancy and risk of endometrial cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

Pre-eclampsia may be associated with the development of endometrial cancer; however, previous findings have been conflicting.

Objectives

To investigate if pre-eclampsia is associated with an increased risk of endometrial cancer.

Method

Two independent reviewers screened titles and abstracts of studies identified in MEDLINE, Embase, and Web of Science databases from inception until March 2022. Studies were included if they investigated pre-eclampsia and subsequent risk of endometrial cancer (or precursor lesions). Random-effects meta-analysis was used to calculate pooled hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between pre-eclampsia during pregnancy and endometrial cancer risk.

Main results

There were seven articles i

SUBMITTER: Jordao H 

PROVIDER: S-EPMC10182685 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature