Hinokitiol-iron complex is a ferroptosis inducer to inhibit triple-negative breast tumor growth.

ABSTRACT:

Background

Ferroptosis is a unique cell death, dependent on iron and phospholipid peroxidation, involved in massive processes of physiopathology. Tremendous attention has been caught in oncology, particularly for those therapy-resistant cancers in the mesenchymal state prone to metastasis due to their exquisite vulnerability to ferroptosis. Therefore, a therapeutical ferroptosis inducer is now underway to be exploited.

Results

A natural compound, hinokitiol (hino), has been considered to be an iron chelator. We have a novel finding that hino complexed with iron to form Fe(hino)₃ can function as a ferroptosis inducer in vitro. The efficiency, compared with the same concentration of iron, increases nearly 1000 folds. Other iron chelators, ferroptosis inhibitors, or

SUBMITTER: Zhao H 

PROVIDER: S-EPMC10182687 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature