Evolutionary Trajectories of New Duplicated and Putative De Novo Genes.

ABSTRACT: The formation of new genes during evolution is an important motor of functional innovation, but the rate at which new genes originate and the likelihood that they persist over longer evolutionary periods are still poorly understood questions. Two important mechanisms by which new genes arise are gene duplication and de novo formation from a previously noncoding sequence. Does the mechanism of formation influence the evolutionary trajectories of the genes? Proteins arisen by gene duplication retain the sequence and structural properties of the parental protein, and thus they may be relatively stable. Instead, de novo originated proteins are often species specific and thought to be more evolutionary labile. Despite these differences, here we show that both types of genes share a number of si

SUBMITTER: Montanes JC 

PROVIDER: S-EPMC10182736 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature