Determinants of medication adherence in childhood nephrotic syndrome and associations of adherence with clinical outcomes.

ABSTRACT:

Background

Pediatric patients with nephrotic syndrome take medications long-term with significant toxicity and complex regimens, yet data on medication adherence are limited.

Methods

In a multicenter observational study of patients with nephrotic syndrome, NEPTUNE (NCT01209000), we surveyed caregivers of patients <19 years old and adolescent patients on medication adherence during longitudinal follow-up beginning in June 2015. Data extraction was in October 2020. We described the proportion of nonadherent patients at first survey. Participant social and economic factors, condition-related factors, therapy-related factors, and patient-related factors were examined for relationships with nonadherence by generalized linear mixed models using the longitudinal data. In explorator

SUBMITTER: Wang CS 

PROVIDER: S-EPMC10182827 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature