Differential inflammatory profile in the lungs of mice exposed to cannabis smoke with varying THC:CBD ratio.

ABSTRACT: Cannabis contains cannabinoids including Δ⁹-tetrahydrocannabinol (THC) and cannabidiol (CBD). THC causes the psychoactive effects of cannabis, and both THC and CBD are thought to be anti-inflammatory. Cannabis is typically consumed by inhaling smoke that contains thousands of combustion products that may damage the lungs. However, the relationship between cannabis smoke exposure and alterations in respiratory health is poorly defined. To address this gap in knowledge, we first developed a mouse model of cannabis smoke exposure using a nose-only rodent inhalation exposure system. We then tested the acute effects of two dried cannabis products that differ substantially in their THC-CBD ratio: Indica-THC dominant (I-THC; 16-22% THC) and Sativa-CBD dominant (S-CBD; 13-19% CBD). We d

SUBMITTER: Haidar Z 

PROVIDER: S-EPMC10183104 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature