Upregulated expression of Notch1/4 - JAG-1/DLL-1 detected in allergic rhinitis.

ABSTRACT:

Background

Allergic rhinitis (AR) is a chronic disease with high prevalence. There are currently many treatments available. However, despite an often good therapeutic response, many patients still report impairment in quality of life (QoL) during the pollen season. A skewed T helper (Th)2 polarization is a well-acknowledged pathologic feature of AR. In animal models, local notch signaling in peripheral tissue seems crucial for Th2 cell differentiation and the development of AR. However, the involvement of Notch signaling in Th2 cell differentiation and the development of AR in humans remains unknown. Hence, the present study investigated the human expression of Notch receptors on CD4⁺ T-cells in nasal mucosa and blood. Correspondingly Notch ligand expression was assessed

SUBMITTER: Hjalmarsson E 

PROVIDER: S-EPMC10183115 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature