Traffic-related air pollution and supplemental folic acid intake in relation to DNA methylation in granulosa cells.

ABSTRACT:

Background

Higher exposure to traffic-related air pollution (TRAP) is related to lower fertility, with specific adverse effects on the ovary. Folic acid may attenuate these effects. Our goal was to explore the relation of TRAP exposure and supplemental folic acid intake with epigenetic aging and CpG-specific DNA methylation (DNAm) in granulosa cells (GC). Our study included 61 women undergoing ovarian stimulation at a fertility center (2005-2015). DNAm levels were profiled in GC using the Infinium MethylationEPIC BeadChip. TRAP was defined using a spatiotemporal model to estimate residence-based nitrogen dioxide (NO₂) exposure. Supplemental folic acid intake was measured with a validated food frequency questionnaire. We used linear regression to evaluate whether NO₂

SUBMITTER: Gaskins AJ 

PROVIDER: S-EPMC10183139 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature