Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS-CoV-2.

ABSTRACT: The coronavirus disease 2019 (COVID-19) pandemic has affected a large portion of the global population, both physically and mentally. Current evidence suggests that the rapidly evolving coronavirus subvariants risk rendering vaccines and antibodies ineffective due to their potential to evade existing immunity, with enhanced transmission activity and higher reinfection rates that could lead to new outbreaks across the globe. The goal of viral management is to disrupt the viral life cycle as well as to relieve severe symptoms such as lung damage, cytokine storm, and organ failure. In the fight against viruses, the combination of viral genome sequencing, elucidation of the structure of viral proteins, and identifying proteins that are highly conserved across multiple coronaviruses has reveale

SUBMITTER: Xue Y 

PROVIDER: S-EPMC10183156 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature