Genetic profile of thymic epithelial tumors in the Japanese population: an exploratory study examining potential therapeutic targets.

ABSTRACT:

Background

Thymic epithelial tumors (TETs) are prone to developing in East Asian populations. However, little is known about the genomic profile of TETs in East Asian populations, and the genomic aberrations in TETs have not yet been fully clarified. Thus, molecular targeted therapies for patients with TETs have not been established. This prospective study was conducted to explore the genetic abnormalities of surgically resected TETs in a Japanese cohort and to identify clues for carcinogenesis and potential therapeutic targets in TETs.

Methods

Genetic profiles of TETs were investigated using fresh-frozen specimens resected from operable cases with TETs. DNA sequencing was performed using a next-generation sequencing (NGS) gene panel test with Ion Reporter™ and CLC Genomics

SUBMITTER: Shimada M 

PROVIDER: S-EPMC10183388 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature