Development of a cuproptosis-related signature for prognosis prediction in lung adenocarcinoma based on WGCNA.

ABSTRACT:

Background

Cuproptosis is a novel mitochondrial respiration-dependent cell death mechanism induced by copper that can kill cancer cells via copper carriers in cancer therapy. However, the clinical significance and prognostic value of cuproptosis in lung adenocarcinoma (LUAD) remains unclear.

Methods

We performed a comprehensive bioinformatics analysis of the cuproptosis gene set, including copy number aberration, single-nucleotide variation, clinical characteristics, survival analysis, etc. Cuproptosis-related gene set enrichment scores (cuproptosis Z-scores) were calculated in The Cancer Genome Atlas (TCGA)-LUAD cohort using single-sample gene set enrichment analysis (ssGSEA). Modules significantly associated with cuproptosis Z-scores were screened by weighted gene co-expre

SUBMITTER: Ling X 

PROVIDER: S-EPMC10183398 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature