Efficacy of different therapies for brain metastases of non-small cell lung cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

As one of the most common causes of death in advanced non-small cell lung cancer (NSCLC), brain metastases (BM) have attracted attention and debate about treatment options, especially for patients with negative driver genes or resistance to targeted agents. Therefore, we conducted a meta-analysis to investigate the potential benefit of different therapeutic regimens for intracranial lesions in non-targeted therapy NSCLC patients.

Methods

A comprehensive search was conducted in databases including PubMed, Embase, and the Cochrane Library. The primary endpoints included the intracerebral objective response rate (icORR) and intracerebral progression-free survival (iPFS) in patients with BM.

Results

Thirty-six studies involving 1,774 NSCLC patients with baselin

SUBMITTER: Chen M 

PROVIDER: S-EPMC10183403 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature