A narrative review from gut to lungs: non-small cell lung cancer and the gastrointestinal microbiome.

ABSTRACT:

Background and objective

The gut microbiome has emerged as an important gateway to improving therapeutic outcomes in lung cancer, especially for immunotherapy. Our objective is to review the impact of the bidirectional relationship between the gut microbiome, lung cancer, and the immune system, and to identify areas of future research.

Methods

We conducted a search on PubMed, EMBASE, and ClinicalTrials.gov using the search terms non-small cell lung cancer (NSCLC), gut microbiome, and microbiota until July 11, 2022. The authors screened resulting studies independently. Results were synthesized and presented descriptively.

Key content and findings

Sixty original published studies were identified from PubMed (n=24) and EMBASE (n=36), respectively. Twenty-five ongoing cli

SUBMITTER: Shah H 

PROVIDER: S-EPMC10183407 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature