Significance of circulating tumor cells in lung cancer: a narrative review.

ABSTRACT:

Background and objective

In cancer patients, circulating tumor cells (CTCs) are employed as "Liquid Biopsy" for tumor detection, prognosis and assessment of the response to therapy. CTCs are responsible for tumor dissemination but the mechanisms involved in intravasation, survival in the circulation and extravasation at secondary sites to establish metastases are not fully characterized. In lung cancer patients, CTCs are present in very high numbers in small cell lung cancer (SCLC) that is found disseminated in most patients upon first presentation and has a dismal prognosis. This review aims at the discussion of recent work on metastatic SCLC and novel insights into the process of dissemination derived from the access to a panel of unique SCLC CTC lines.

Methods

PubMed and

SUBMITTER: Hamilton G 

PROVIDER: S-EPMC10183408 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature