Placental microRNAs relate to early childhood growth trajectories.

ABSTRACT:

Background

Poor placental function is a common cause of intrauterine growth restriction, which in turn is associated with increased risks of adverse health outcomes. Our prior work suggests that birthweight and childhood obesity-associated genetic variants functionally impact placental function and that placental microRNA are associated with birthweight. To address the influence of the placenta beyond birth, we assessed the relationship between placental microRNAs and early childhood growth.

Methods

Using the SITAR package, we generated two parameters that describe individual weight trajectories of children (0-5 years) in the New Hampshire Birth Cohort Study (NHBCS, n = 238). Using negative binomial generalized linear models, we identified placental microRNAs that relate to

SUBMITTER: Kennedy EM 

PROVIDER: S-EPMC10183479 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature