Preoperative umeclidinium/vilanterol or tiotropium improves postoperative FEV₁ in lung cancer patients with comorbid untreated chronic obstructive pulmonary disease.

ABSTRACT:

Background

This study aimed to examine the effects of preoperative interventions in lung cancer patients with untreated chronic obstructive pulmonary disease (COPD). We evaluated the efficiency of preoperative interventions using tiotropium (TIO) or umeclidinium/vilanterol (UMEC/VI).

Methods

We conducted a two-center retrospective study. Perioperative forced expiratory volume in 1 second (FEV₁) was compared between a preoperative COPD intervention group and an untreated group. COPD therapeutic drugs were started 2 weeks before surgery and were continued until 3 months after surgery. Radical lobectomy was performed in patients with an FEV₁ of ≥1.5 L.

Results

A total of 92 patients were enrolled (untreated, 31 patients; intervention, 61 patients).

SUBMITTER: Homma T 

PROVIDER: S-EPMC10183516 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature