Immune characteristics and genetic markers of esophageal cancer by single-cell analysis: implications for immunotherapy.

ABSTRACT:

Background

Esophageal cancer (EC) is one of the most common cancers worldwide. The prognoses for patients with the same stage of EC can vary substantially. The progress of single-cell analysis technology has furthered the understanding of tumor heterogeneity. This paper aimed to apply single-cell analysis to explore the characteristics of the tumor environment of EC and provide a basis for personalized treatment.

Methods

The latest gene expression data and clinical follow-up information of single-cell sequencing results of EC samples were downloaded from The Cancer Genome Atlas (TCGA) Genomic Data Commons (GDC) Application Programming Interface (API). A differential gene function analysis of the immune infiltration signature agents in the tumor microenvironment (TME) was per

SUBMITTER: Xu B 

PROVIDER: S-EPMC10183529 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature