Dysregulated expression of microRNA involved in resistance to osimertinib in EGFR mutant non-small cell lung cancer cells.

ABSTRACT:

Background

An increasing amount of evidence has confirmed that the altered expression of microRNAs (miRNAs) is critical to the mechanism underlying primary and even acquired resistance to tyrosine kinase inhibitors (TKIs). However, studies on the linkage between the altered miRNAs expression and osimertinib resistance are few, and the effect of miRNAs in this context is still unclear. In the light of this, we hypothesized that the differential expression of multiple miRNAs is the driver in the osimertinib resistance process. Thus, the aim of our study was to find differentially expressed miRNAs in non-small cell lung cancer cells resistant to osimertinib.

Methods

An AZD9291(Osimertinib)-resistant cell line model was constructed, and the differential miRNAs between epidermal

SUBMITTER: Zhang D 

PROVIDER: S-EPMC10183542 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature