Construction of a prognostic model for lung adenocarcinoma based on membrane-tension-related genes.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD), which is the most common type of non-small cell lung cancer (NSCLC), is one of the most aggressive and fatal tumors. Therefore, the identification of key biomarkers affecting prognosis is important to improving the prognosis of patients with LUAD. Cell membranes have long been understood; however, few studies have focused on the role of membrane tension in LUAD. The present study aimed to construct a prognostic model associated with membrane-tension-related genes (MRGs) and explore its prognostic value in LUAD patients.

Methods

RNA sequencing data and the corresponding clinical characteristics data of LUAD were obtained from The Cancer Genome Atlas (TCGA) database. Five membrane-tension prognosis-related genes (5-MRG) were screened by u

SUBMITTER: Zhu P 

PROVIDER: S-EPMC10183546 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature