Pathogenesis and management of gastroesophageal reflux disease-associated cough: a narrative review.

ABSTRACT:

Background and objective

Gastroesophageal reflux disease (GERD)-associated cough is defined as a special GERD with a predominant cough symptom and is a common cause of chronic cough. This review summarizes our current understanding on the pathogenesis and management of GERD-associated cough.

Methods

Main literatures on the pathogenesis and management of GERD-associated cough were reviewed and our understandings derived from the published studies were showed then.

Key content and findings

Although esophageal-tracheobronchial reflex mainly underlies the pathogenesis of GERD-associated cough, its counterpart-tracheobronchial-esophageal reflex might exist and initiate the cough due to reflux induced by upper respiratory tract infection through the signaling of transient r

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10183548 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature