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Case Report: Double trouble: a rare case of successfully treated Mycoplasma hominis and Pseudomonas aeruginosa co-infection.

ABSTRACT:

Background

Extra-urogenital infections due to Mycoplasma hominis (M. hominis) are rare, particularly co-infection with Pseudomonas aeruginosa (P. aeruginosa). Herein, we report on a patient who was co-infected and successfully treated despite delayed treatment.

Case presentation

We reported the case of a 43-year-old man with M. hominis and P. aeruginosa co-infection after a traffic accident. The patient developed a fever and severe infection despite postoperative antimicrobial therapies. The blood culture of wound tissues was positive for P. aeruginosa. Meanwhile, culturing of blood and wound samples showed pinpoint-sized colonies on blood agar plates and fried-egg-type colonies on mycoplasma medium, which were identified as M. hominis by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) and 16S rRNA sequencing. Based on antibiotic susceptibility and symptoms, ceftazidime-avibactam and moxifloxacin were administered for P. aeruginosa infection. Meanwhile, after the failure of a series of anti-infective agents, M. hominis and P. aeruginosa co-infection was successfully treated with a minocycline-based regimen and polymyxin B.

Conclusion

The co-infection with M. hominis and P. aeruginosa was successfully treated with anti-infective agents despite delayed treatment, providing information for the management of double infection.

SUBMITTER: Huang SM

PROVIDER: S-EPMC10183579 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Case Report: Double trouble: a rare case of successfully treated <i>Mycoplasma hominis</i> and <i>Pseudomonas aeruginosa</i> co-infection.

Huang Shi-Mei SM Tang Yu-Rong YR Wang Ji-Liang JL Wang Xiao-Zhen XZ Zhang Yuan-Yuan YY Pan Su-Fei SF

Frontiers in cellular and infection microbiology 20230501

<h4>Background</h4>Extra-urogenital infections due to <i>Mycoplasma hominis</i> (<i>M. hominis</i>) are rare, particularly co-infection with <i>Pseudomonas aeruginosa</i> (<i>P. aeruginosa</i>). Herein, we report on a patient who was co-infected and successfully treated despite delayed treatment.<h4>Case presentation</h4>We reported the case of a 43-year-old man with <i>M. hominis</i> and <i>P. aeruginosa</i> co-infection after a traffic accident. The patient developed a fever and severe infecti ...[more]

PMID: 37197207

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