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Mechanism and evolution of human ACE2 binding by SARS-CoV-2 spike.

ABSTRACT: Spike glycoprotein of SARS-CoV-2 mediates viral entry into host cells by facilitating virus attachment and membrane fusion. ACE2 is the main receptor of SARS-CoV-2 and its interaction with spike has shaped the virus' emergence from an animal reservoir and subsequent evolution in the human host. Many structural studies on the spike:ACE2 interaction have provided insights into mechanisms driving viral evolution during the on-going pandemic. This review describes the molecular basis of spike binding to ACE2, outlines mechanisms that have optimised this interaction during viral evolution, and suggests directions for future research.

SUBMITTER: Wrobel AG

PROVIDER: S-EPMC10183628 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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Mechanism and evolution of human ACE2 binding by SARS-CoV-2 spike.

Wrobel Antoni G AG

Current opinion in structural biology 20230515

Spike glycoprotein of SARS-CoV-2 mediates viral entry into host cells by facilitating virus attachment and membrane fusion. ACE2 is the main receptor of SARS-CoV-2 and its interaction with spike has shaped the virus' emergence from an animal reservoir and subsequent evolution in the human host. Many structural studies on the spike:ACE2 interaction have provided insights into mechanisms driving viral evolution during the on-going pandemic. This review describes the molecular basis of spike bindin ...[more]

PMID: 37285618

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