Association between HSP-Specific T-Cell Counts and Retinal Nerve Fiber Layer Thickness in Patients with Primary Open-Angle Glaucoma.

ABSTRACT:

Objective

Previous laboratory reports implicate heat shock protein (HSP)-specific T-cell responses in glaucoma pathogenesis; here, we aimed to provide direct clinical evidence by correlating systemic HSP-specific T-cell levels with glaucoma severity in patients with primary open-angle glaucoma (POAG).

Design

Cross-sectional case-control study.

Subjects

Thirty-two adult patients with POAG and 38 controls underwent blood draw and optic nerve imaging.

Methods

Peripheral blood monocytes (PBMC) were stimulated in culture with HSP27, α-crystallin, a member of the small HSP family, or HSP60. Both interferon-γ (IFN-γ)+ CD4+ T helper type 1 cells (Th1) and transforming growth factor-β1 (TGF-β1)+ CD4+ regulatory T cells (Treg) were quantified by flow cytometry and presen

SUBMITTER: Saini C 

PROVIDER: S-EPMC10183658 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature