Geographic Atrophy in Age-Related Macular Degeneration: A Tale of Two Stages.

ABSTRACT:

Purpose

To examine disease progression in age-related macular degeneration (AMD) at 2 distinct stages, progression to geographic atrophy (GA) versus GA expansion, by comparison of the risk and protective factors at each stage.

Design

Perspective.

Subjects

Individuals at risk of GA or with GA.

Main outcome measures

Progression to GA and GA expansion rate.

Methods

Critical synthesis of the literature on risk and protective factors, both environmental and genetic, for progression to GA versus GA expansion in AMD.

Results

Comparison of the risk and protective factors demonstrates partially overlapping but partially distinct risk and protective factors for progression to GA versus GA expansion. Some factors are shared (i.e., operating in the same direc

SUBMITTER: Keenan TDL 

PROVIDER: S-EPMC10183660 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature