Up-regulation of PRKDC was associated with poor renal dysfunction after renal transplantation: A multi-centre analysis.

ABSTRACT: Renal transplantation is the only efficacious treatment for end-stage kidney disease. However, some people have developed renal insufficiency after transplantation, the mechanisms of which have not been well clarified. Previous studies have focused on patient factors, while the effect of gene expression in the donor kidney on post-transplant renal function has been less studied. Donor kidney clinical data and mRNA expression status were extracted from the GEO database (GSE147451). Weight gene co-expression network analysis (WGCNA) and differential gene enrichment analysis were performed. For external validation, we collected data from 122 patients who accepted renal transplantation at several hospitals and measured the level of target genes by qPCR. This study included 192 patients from th

SUBMITTER: Cao Z 

PROVIDER: S-EPMC10183702 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature