Age-dependent changes in the dynamic functional organization of the brain at rest: a cross-cultural replication approach.

ABSTRACT: Age-associated changes in brain function play an important role in the development of neurodegenerative diseases. Although previous work has examined age-related changes in static functional connectivity, accumulating evidence suggests that advancing age is especially associated with alterations in the dynamic interactions and transitions between different brain states, which hitherto have received less attention. Conclusions of previous studies in this domain are moreover limited by suboptimal replicability of resting-state functional magnetic resonance imaging (fMRI) and culturally homogenous cohorts. Here, we investigate the robustness of age-associated changes in dynamic functional connectivity (dFC) by capitalizing on the availability of fMRI cohorts from two cultures (Western Europea

SUBMITTER: Yang X 

PROVIDER: S-EPMC10183740 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature