Selective Hydrolysis of Nonactivated Aryl Esters at pH 7 through Cooperative Catalysis.

ABSTRACT: Most reported artificial esterases only hydrolyze highly activated substrates. We here report synthetic catalysts that hydrolyze nonactivated aryl esters at pH 7, via cooperative action of a thiourea group that mimics the oxyanion hole of a serine protease and a nearby nucleophilic/basic pyridyl group. The molecularly imprinted active site distinguishes subtle structural changes in the substrate, including elongation of the acyl chain by two carbons or shift of a remote methyl group by one carbon.

SUBMITTER: Arifuzzaman MD 

PROVIDER: S-EPMC10183976 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature