Early-life determinants of childhood plasma insulin levels: implications for primordial prevention of diabetes.

ABSTRACT:

Background

We earlier reported prematurity as an independent risk factor for elevated insulin levels. Investigation is still lacking on the influence of prenatal and perinatal factors on childhood insulin levels.

Methods

In this secondary analysis of a prospective birth cohort, plasma insulin levels were measured at birth and early childhood. Regression models identified early-life factors associated with the primary outcome: log-transformed childhood plasma insulin levels.

Results

One thousand one hundred and nine children had insulin levels at birth and 825 at both time points. Compared to term, preterm infants had higher plasma insulin levels (geometric mean) at birth (612, 95% CI 552-679 vs. 372, 95% CI 345-402 pmol/ml) and in early childhood (547, 95% CI 494-605

SUBMITTER: Makker K 

PROVIDER: S-EPMC10184189 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature